{"id":1,"date":"2024-02-02T00:56:51","date_gmt":"2024-02-02T00:56:51","guid":{"rendered":"https:\/\/screen-inc.com\/mobindo\/?p=1"},"modified":"2024-02-21T19:02:37","modified_gmt":"2024-02-22T03:02:37","slug":"within-session-learning-predicts-elevated-brain-amyloid","status":"publish","type":"post","link":"https:\/\/staging.screen-inc.com\/?p=1","title":{"rendered":"Within-session Learning of an Object Identification Task Predicts Elevated Brain A\u03b2"},"content":{"rendered":"\n<p><em>In further analysis from a&nbsp;multi-year study of 81 adults&nbsp;conducted by the Kentucky Neuroscience Institute, the CANS-MCI has been as shown to be predictively sensitive to heightened CSF levels of A\u03b2 and tau.<\/em><\/p>\n\n\n\n<p>CSF was collected from participants near to the time of completing the baseline Computer- Administered Neuropsychological Screen for MCI (CANS). CSF levels of A\u03b2 (threshold = 250pg\/ml) were used to group participants as elevated (A\u03b2+) and not elevated (A\u03b2-) brain amyloid. A linear mixed model (LMM) with object identification response time at each (correct) trial as the dependent variable and age, sex, education, depression, and trial as independent variables, a random slope of trial for participants. Slope for each participant was extracted and used to predict brain amyloid status and mean response time on the same task 6 months later (logistic regressions).<\/p>\n\n\n\n<p>Results: Of 96 participants, 57 were A\u03b2- and 39 were A\u03b2+. The groups did not differ statistically in sex, education, depression, or prior CANS administrations, ps &gt; 0.33. The A\u03b2+ group (76.6y) was slightly older than A\u03b2- (73.9y), p =0.05. The LMM indicated age (\u03b2 = 0.02, p &lt; 0.001) and depression (\u03b2 = 0.03, p = 0.04) significantly slowed response time, and response time was significantly faster with successive trials (\u03b2 = -0.04, p &lt; 0.001). Age (\u03b2 = -0.06, p = 0.06) and participant slopes for trial (\u03b2 = -75.16, p = 0.01) correctly classified 36 A\u03b2- (63.2%) and 28 A\u03b2+ (71.8%) participants. For the A\u03b2+ group, follow-up response times varied little by slope, whereas A\u03b2- participants with steeper slopes had faster times at follow-up.<\/p>\n\n\n\n<p>Conclusion: A\u03b2+participants exhibited significantly steeper learning slopes than A\u03b2-. This may reflect slight retrieval delays early in the task and subsequent hyperactivation. Learning slopes at baseline also predicted improved performance at follow-up, in line with existing research on within-session practice effects. Implications and future directions discussed.<\/p>\n\n\n\n<p><a href=\"https:\/\/staging.screen-inc.com\/?sdm_process_download=1&amp;download_id=982\">Download the AAIC 2019 poster<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In further analysis from a&nbsp;multi-year study of 81 adults&nbsp;conducted by the Kentucky Neuroscience Institute, the CANS-MCI has been as shown to be predictively sensitive to heightened CSF levels of A\u03b2 and tau. CSF was collected from participants near to the time of completing the baseline Computer- Administered Neuropsychological Screen for MCI (CANS). CSF levels of [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-1","post","type-post","status-publish","format-standard","hentry","category-studies"],"_links":{"self":[{"href":"https:\/\/staging.screen-inc.com\/index.php?rest_route=\/wp\/v2\/posts\/1","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/staging.screen-inc.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/staging.screen-inc.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/staging.screen-inc.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/staging.screen-inc.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1"}],"version-history":[{"count":4,"href":"https:\/\/staging.screen-inc.com\/index.php?rest_route=\/wp\/v2\/posts\/1\/revisions"}],"predecessor-version":[{"id":998,"href":"https:\/\/staging.screen-inc.com\/index.php?rest_route=\/wp\/v2\/posts\/1\/revisions\/998"}],"wp:attachment":[{"href":"https:\/\/staging.screen-inc.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/staging.screen-inc.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/staging.screen-inc.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}