{"id":654,"date":"2024-02-15T13:19:52","date_gmt":"2024-02-15T21:19:52","guid":{"rendered":"https:\/\/staging-u6txq.screen-inc.com\/clone\/?p=654"},"modified":"2024-02-21T19:02:46","modified_gmt":"2024-02-22T03:02:46","slug":"sensitivity-of-the-cans-mci-to-csf-markers-of-preclinical-alzheimers","status":"publish","type":"post","link":"https:\/\/staging.screen-inc.com\/?p=654","title":{"rendered":"Sensitivity of the CANS-MCI to CSF Markers of Preclinical Alzheimer\u2019s"},"content":{"rendered":"\n<p><em>In a\u00a0multi-year study of 81 adults\u00a0conducted by the Kentucky Neuroscience Institute, the CANS-MCI has been shown to be sensitive to heightened CSF levels of A\u03b2 and tau.<\/em><\/p>\n\n\n\n<p>This study examined cerebrospinal fluid (CSF) amyloid \u03b2 1-42 (A\u03b2) and tau levels and performance on a computerized self-administered test battery, the Computer-Administered Neuropsychological Screen for MCI (CANS-MCI).<\/p>\n\n\n\n<p>Methods: CSF was collected from participants who also completed the CANS-MCI near to the time of collection. CSF levels of A\u03b2 (threshold = 250pg\/ml) and tau (93pg\/ml) were used to segment participants: A\u03b2-Tau-, A\u03b2+Tau-, and A\u03b2+Tau+, with positivity indicating increasing brain deposition and likely preclinical Alzheimer\u2019s disease (AD). ANOVAs and Chi-square tests were used to compare group demographics. Linear regressions were used to compare CANS-MCI performance between groups while controlling for age, sex, education, prior CANS-MCI, and processing speed.<\/p>\n\n\n\n<p>Results: Participants were 81 adults, ages 65 to 94; 51.8% females. The A\u03b2+Tau- group (mean age = 78, SD = 6.8) was significantly older than A\u03b2-Tau- (mean age= 73.6, SD = 6.3), p = 0.032, but not A\u03b2+Tau+ (mean = 76.3, SD = 7.5); no other group differences in age. All participants were Caucasian except 3, who belonged to unique ethnic minority groups. Gender, education, depression, prior CANS-MCI administrations, and time between CSF collection and CANS-MCI completion were similar between groups. Processing speed significantly slowed with age (r = 0.27, p = 0.02).<\/p>\n\n\n\n<p><strong>Compared to the A\u03b2-Tau- group, the A\u03b2+Tau- and A\u03b2+Tau+ groups evidenced CANS-MCI performance deficits in memory, visuospatial, and executive domains. The A\u03b2+Tau+ group performed below the A\u03b2-Tau- group on the test of language fluency.<\/strong><\/p>\n\n\n\n<p>Conclusions: Although the cohort was relatively homogeneous and other factors known to affect test performance were unaccounted for, this study demonstrated that&nbsp;<strong><em>performance on the CANS-MCI is sensitive to heightened A\u03b2 and tau brain deposition.<\/em><\/strong><\/p>\n\n\n\n<p>Future studies should examine CANS-MCI performance over time in relation to changes in A\u03b2 and tau CSF levels as well as the utility of the CANS-MCI in predicting preclinical AD.<\/p>\n\n\n\n<p><a href=\"https:\/\/staging.screen-inc.com\/?sdm_process_download=1&amp;download_id=995\">Download the 2018 AAIC poster here.<\/a><\/p>\n\n\n\n<p>See the\u00a0<a href=\"https:\/\/www.researchgate.net\/publication\/327652918_CSF_Markers_of_Preclinical_AD_Deficits_on_a_Self-Administered_Computerized_Test_Battery\" target=\"_blank\" rel=\"noreferrer noopener\">AAIC 2018 Poster online<\/a>\u00a0at researchgate.net.<\/p>\n\n\n\n<p>Justin Barber et al<br>University of Kentucky, Lexington, KY<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a\u00a0multi-year study of 81 adults\u00a0conducted by the Kentucky Neuroscience Institute, the CANS-MCI has been shown to be sensitive to heightened CSF levels of A\u03b2 and tau. This study examined cerebrospinal fluid (CSF) amyloid \u03b2 1-42 (A\u03b2) and tau levels and performance on a computerized self-administered test battery, the Computer-Administered Neuropsychological Screen for MCI (CANS-MCI). [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-654","post","type-post","status-publish","format-standard","hentry","category-studies"],"_links":{"self":[{"href":"https:\/\/staging.screen-inc.com\/index.php?rest_route=\/wp\/v2\/posts\/654","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/staging.screen-inc.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/staging.screen-inc.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/staging.screen-inc.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/staging.screen-inc.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=654"}],"version-history":[{"count":3,"href":"https:\/\/staging.screen-inc.com\/index.php?rest_route=\/wp\/v2\/posts\/654\/revisions"}],"predecessor-version":[{"id":997,"href":"https:\/\/staging.screen-inc.com\/index.php?rest_route=\/wp\/v2\/posts\/654\/revisions\/997"}],"wp:attachment":[{"href":"https:\/\/staging.screen-inc.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=654"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/staging.screen-inc.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=654"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/staging.screen-inc.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=654"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}